Journal Article

Azole-Resistant Central Nervous System Aspergillosis

Jan W. M. van der Linden, Rogier R. Jansen, Dorine Bresters, Caroline E. Visser, Suzanne E. Geerlings, Ed J. Kuijper, Willem J.G. Melchers and Paul E. Verweij

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 48, issue 8, pages 1111-1113
Published in print April 2009 | ISSN: 1058-4838
Published online April 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/597465
Azole-Resistant Central Nervous System Aspergillosis

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Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34–base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly complicates the management of aspergillosis by delaying the initiation of adequate therapy and because effective alternative antifungal drugs are lacking.

Journal Article.  1970 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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