Journal Article

Chagas' Disease in Patients with Kidney Transplants: 7 Years of Experience, 1989–1996

A. Riarte, C. Luna, R. Sabatiello, A. Sinagra, R. Schiavelli, A. De Rissio, E. Maiolo, M. M. García, N. Jacob, M. Pattin, M. Lauricella, E. L. Segura and M. Vàzquez

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 29, issue 3, pages 561-567
Published in print September 1999 | ISSN: 1058-4838
Published online September 1999 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/598634
Chagas' Disease in Patients with Kidney Transplants: 7 Years of Experience, 1989–1996

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Chagas' disease was present in 17.22% of persons undergoing kidney transplantation in an Argentine Hospital. The criterion for attributing reactivation of chronic Chagas' disease and transmission of Trypanosoma cruzi to grafts was detection of parasites in blood (patent parasitemia) or tissues. Reactivation was diagnosed in 5 (21.7%) of 23 recipients. Ten (43.4%) of 23 chagasic recipients without reactivation of chronic Chagas' disease had abrogation of serological reactivity. T. cruzi infection was transmitted to 3 (18.7%) of 16 non-chagasic recipients. Reactivation and infection were diagnosed by patent parasitemia or cutaneous panniculitis. For diagnosis, detection of parasites in blood and tissues had more relevance than serology. Sequential monitoring detected early reactivation and infection, permitting application of preemptive or therapeutic therapy with benznidazole, thus inhibiting, in all patients, severe clinical disease produced by a progressive and systemic replication of the parasite.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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