Journal Article

Efavirenz Treatment and False-Positive Results in Benzodiazepine Screening Tests

Antje Blank, Victoria Hellstern, Dieter Schuster, Martin Hartmann, Anne K. Matthée, Jürgen Burhenne, Walter E. Haefeli and Gerd Mikus

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 48, issue 12, pages 1787-1789
Published in print June 2009 | ISSN: 1058-4838
Published online June 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/599109
Efavirenz Treatment and False-Positive Results in Benzodiazepine Screening Tests

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We investigated the effect of efavirenz treatment on the results of drug screening tests of urine samples obtained from 100 patients infected with human immunodeficiency virus. Of 50 patients who received efavirenz, 49 tested positive for benzodiazepines in ⩾1 drug screening test, whereas of 50 patients who did not receive efavirenz, only 1 tested positive for benzodiazepines in ⩾1 drug screening test. The major metabolite 8-hydroxy-efavirenz is responsible for this cross-reactivity.

Journal Article.  1907 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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