Journal Article

Doripenem: A New Carbapenem in the Treatment of Nosocomial Infection

Lionel Mandell

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue Supplement_1, pages S1-S3
Published in print August 2009 | ISSN: 1058-4838
Published online August 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/599809
Doripenem: A New Carbapenem in the Treatment of Nosocomial Infection

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Difficult-to-treat infections caused by gram-negative pathogens are common in the hospital setting, particularly those caused by Pseudomonas aeruginosa, Acinetobacter species, and extended-spectrum β-lactamase-producing Enterobacteriaceae, all of which are capable of developing resistance to common antimicrobial agents. New drugs are urgently needed to combat this threat. In this supplement, researchers in infectious diseases discuss the role of doripenem, a newly approved carbapenem, in the treatment of serious nosocomial infections and review new data on doripenem for the treatment of nosocomial pneumonia, including ventilator-associated pneumonia. The topics addressed include antimicrobial resistance and the available therapeutic options against gram-negative pathogens, the in vitro activity of doripenem, the efficacy and safety of intravenous infusion of doripenem, and the clinical and economic consequences of ventilator-associated pneumonia. Based on the strength of the clinical evidence presented, doripenem appears to provide broad-spectrum coverage and antipseudomonal activity, leading to advantageous clinical outcomes, particularly in patients at risk of infection with drug-resistant pathogens.

Journal Article.  1849 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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