Journal Article

Dexamethasone in <i>Cryptococcus gattii</i> Central Nervous System Infection

Peter Phillips, Kristine Chapman, Madeleine Sharp, Phil Harrison, Jerry Vortel, Theodore Steiner and William Bowie

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue 4, pages 591-595
Published in print August 2009 | ISSN: 1058-4838
Published online August 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/603554
Dexamethasone in Cryptococcus gattii Central Nervous System Infection

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Clinical outcomes were reviewed for 4 patients with Cryptococcus gattii central nervous system infection who received dexamethasone for the treatment of persisting mental status abnormalities and focal lesions on brain scan despite culture-negative cerebrospinal fluid and the management of intracranial pressure. Favorable clinical responses were observed in 3 patients. Although corticosteroids are not recommended for the treatment of cryptococcal meningitis, these observations suggest that dexamethasone should be further evaluated in this subset of patients.

Journal Article.  1928 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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