Journal Article

Cryptococcal Immune Reconstitution Inflammatory Syndrome after Antiretroviral Therapy in AIDS Patients with Cryptococcal Meningitis: A Prospective Multicenter Study

Somnuek Sungkanuparph, Scott G. Filler, Ploenchan Chetchotisakd, Peter G. Pappas, Tracy L. Nolen, Weerawat Manosuthi, Thanomsak Anekthananon, Michele I. Morris, Khuanchai Supparatpinyo, Heather Kopetskie, Amy S. Kendrick, Philip C. Johnson, Jack D. Sobel and Robert A. Larsen

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue 6, pages 931-934
Published in print September 2009 | ISSN: 1058-4838
Published online September 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/605497
Cryptococcal Immune Reconstitution Inflammatory Syndrome after Antiretroviral Therapy in AIDS Patients with Cryptococcal Meningitis: A Prospective Multicenter Study

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A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.

Journal Article.  2308 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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