Journal Article

Herpes Simplex Encephalitis during Treatment with Tumor Necrosis Factor-α Inhibitors

Russell D. Bradford, April C. Pettit, Patty W. Wright, Mark J. Mulligan, Larry W. Moreland, David A. McLain, John W. Gnann and Karen C. Bloch

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue 6, pages 924-927
Published in print September 2009 | ISSN: 1058-4838
Published online September 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/605498
Herpes Simplex Encephalitis during Treatment with Tumor Necrosis Factor-α Inhibitors

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We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor-alpha (TNF-α) inhibitors for rheumatologic disorders. Although TNF-α inhibitors have been reported to increase the risk of other infectious diseases, to our knowledge, an association between anti-TNF-α drugs and herpes simplex virus encephalitis has not been previously described.

Journal Article.  2318 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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