Journal Article

Toxicodynamics of Itraconazole: Implications for Therapeutic Drug Monitoring

Jodi M. Lestner, Steven A. Roberts, Caroline B. Moore, Susan J. Howard, David W. Denning and William W. Hope

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue 6, pages 928-930
Published in print September 2009 | ISSN: 1058-4838
Published online September 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/605499
Toxicodynamics of Itraconazole: Implications for Therapeutic Drug Monitoring

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We explored concentration-toxicity relationships for itraconazole among 216 patients. Logistic regression revealed a progressive increase in the probability of toxicity with increasing concentrations of itraconazole. Classification and regression tree analysis suggested that 17.1 mg/L of itraconazole (measured using a bioassay) was the concentration level at which the population of patients was separated into 2 groups, each with a high and a low probability of toxicity.

Journal Article.  2098 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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