Journal Article

Very Late-Onset Group B <i>Streptococcus</i> Meningitis, Sepsis, and Systemic Shigellosis due to Interleukin-1 Receptor-Associated Kinase-4 Deficiency

Jens C. Krause, Pegah Ghandil, Maya Chrabieh, Jean-Laurent Casanova, Capucine Picard, Anne Puel and C. Buddy Creech

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue 9, pages 1393-1396
Published in print November 2009 | ISSN: 1058-4838
Published online November 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/630206
Very Late-Onset Group B Streptococcus Meningitis, Sepsis, and Systemic Shigellosis due to Interleukin-1 Receptor-Associated Kinase-4 Deficiency

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We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1β or lipopolysaccharide. Sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations.

Journal Article.  2030 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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