Journal Article

The R753Q Polymorphism Abrogates Toll-Like Receptor 2 Signaling in Response to Human Cytomegalovirus

Robert A. Brown, Jonathon H. Gralewski and Raymund R. Razonable

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue 9, pages e96-e99
Published in print November 2009 | ISSN: 1058-4838
Published online November 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/644501
The R753Q Polymorphism Abrogates Toll-Like Receptor 2 Signaling in Response to Human Cytomegalovirus

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Toll-like receptor 2 (TLR2) serves as a pattern recognition receptor that signals the presence of cytomegalovirus. Herein, we report that R753Q polymorphism paralyzes TLR2-mediated immune signaling in cells exposed to cytomegalovirus glycoprotein B. This immunologic impairment could serve as a biologic mechanism underlying the association between the TLR2 R753Q polymorphism and cytomegalovirus disease in humans.

Journal Article.  2349 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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