Journal Article

<i>Bordetella pertussis</i> and Pertussis Vaccines

Nicole Guiso

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue 10, pages 1565-1569
Published in print November 2009 | ISSN: 1058-4838
Published online November 2009 | e-ISSN: 1537-6591 | DOI:
Bordetella pertussis and Pertussis Vaccines

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Bordetella pertussis is a human-specific pathogen that causes whooping cough. The use of pertussis whole-cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life-long immunity; indeed, the circulation of the bacterium has not been controlled in the adult population. Universal adult booster immunization is now possible using pertussis acellular vaccines, which target—and are thus likely to control—the virulence of this bacterium.

Journal Article.  3531 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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