Journal Article

T Cell Dynamics and the Response to HAART in a Cohort of HIV-1-Infected Elite Suppressors

Ahmad R. Sedaghat, Darius A. Rastegar, Karen A. O'Connell, Jason B. Dinoso, Claus O. Wilke and Joel N. Blankson

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 49, issue 11, pages 1763-1766
Published in print December 2009 | ISSN: 1058-4838
Published online December 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/648081
T Cell Dynamics and the Response to HAART in a Cohort of HIV-1-Infected Elite Suppressors

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Elite controllers or suppressors are untreated human immunodeficiency virus type 1 (HIV-1)-infected patients who maintain undetectable viral loads. In this study, we show that most elite suppressors do not experience significant changes in T cell counts over a 10-year period. Interestingly, treatment of an elite suppressor with highly active antiretroviral therapy (HAART) led to a marked decrease in immune activation.

Journal Article.  2122 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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