Journal Article

Therapy Failure following Selection of Enfuvirtide-Resistant HIV-1 in Cerebrospinal Fluid

S. F. L. van Lelyveld, M. Nijhuis, F. Baatz, I. Wilting, W. M. van den Bergh, M. Kurowski, D. de Jong, A. I. M. Hoepelman and A. M. J. Wensing

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 50, issue 3, pages 387-390
Published in print February 2010 | ISSN: 1058-4838
Published online February 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/649874
Therapy Failure following Selection of Enfuvirtide-Resistant HIV-1 in Cerebrospinal Fluid

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We report the selection of enfuvirtide-resistant human immunodeficiency virus type 1 in cerebrospinal fluid, resulting in subsequent loss of viral suppression in the plasma. This case report emphasizes the potential danger of low-level penetration of entry inhibitors into the central nervous system.

Journal Article.  2225 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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