Journal Article

Vaccines against Seasonal and Pandemic Influenza and the Implications of Changes in Substrates for Virus Production

Stanley Plotkin and Philip D. Minor

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 50, issue 4, pages 560-565
Published in print February 2010 | ISSN: 1058-4838
Published online February 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/650171
Vaccines against Seasonal and Pandemic Influenza and the Implications of Changes in Substrates for Virus Production

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Influenza virus changes constantly, making vaccine production challenging. Changing the growth substrate from eggs to cell culture raises issues at all stages of the process, from surveillance to the assay of vaccines. The pandemic threat—first H5N1, then H1N1—encouraged a review of methods and brought issues into sharp relief.

Journal Article.  3570 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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