Journal Article

Continuous Infusion of Amphotericin B Deoxycholate in the Treatment of Cryptococcal Meningoencephalitis: Analysis of Safety and Fungicidal Activity

Diego Rodrigues Falci, Luciano Weber Lunardi, Carina Guedes Ramos, Mônica Baumgardt Bay, Valério Rodrigues Aquino and Luciano Zubaran Goldani

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 50, issue 5, pages e26-e29
Published in print March 2010 | ISSN: 1058-4838
Published online March 2010 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/650489
Continuous Infusion of Amphotericin B Deoxycholate in the Treatment of Cryptococcal Meningoencephalitis: Analysis of Safety and Fungicidal Activity

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We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5″flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)–infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony-forming units was comparable to standard 4-h infusion of amphotericin B.

Journal Article.  2030 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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