Journal Article

Cellular CD4 T Cell Responses to the Diphtheria- Derived Carrier Protein of Conjugated Pneumococcal Vaccine and Antibody Response to Pneumococcal Vaccination in HIV-Infected Adults

Claire Rabian, Inga Tschöpe, Philippe Lesprit, Christine Katlama, Jean-Michel Molina, Jean-Luc Meynard, Jean-François Delfraissy, Geneviève Cheêne and Yves Lévy

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 50, issue 8, pages 1174-1183
Published in print April 2010 | ISSN: 1058-4838
Published online April 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/651418
Cellular CD4 T Cell Responses to the Diphtheria- Derived Carrier Protein of Conjugated Pneumococcal Vaccine and Antibody Response to Pneumococcal Vaccination in HIV-Infected Adults

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Background. The French National Agency for AIDS and Viral Hepatitis Research (ANRS) 114 Pneumovac trial showed that a strategy combining a 7-valent pneumococcal conjugate vaccine (PCV) prime at week 0 followed by a 23-valent pneumococcal polysaccharide vaccine (PPV) boost at week 4 enhances the frequency and magnitude of immunoglobulin (Ig) G responses against Streptococcus pneumoniae polysaccharides (SPPs) compared with PPV alone. CD4 T cell responses specific to the diphtheria-derived carrier protein CRM197 were evaluated.

Methods. Lymphocyte proliferative responses (LPRs) and TH1 cytokine T cell responses against the diphtheriaderived carrier protein CRM197 contained in the PCV were investigated at weeks 0, 4, and 24.

Results. In the prime-boost PCV and PPV group, the magnitude of LPRs to diphtheria toxoid and CRM197 increased at week 4 (P < .001) and persisted until week 24 (P = .08 and .13, respectively, compared with week 4). Interferon-γ and interleukin-2 production to CRM197 increased significantly at week 4 (P = .02 and P < .001, respectively) and remained stable until week 24 (P = .28 and P = .08, respectively). No changes were detected in the PPV group. A strong association among the magnitude of LPRs to CRM197 at week 4, the breadth of SPP specific IgG responses at week 8 (P = .03), and sustained IgG responses at week 24 was observed. A high frequency of helper follicular CD4+CXCR5+ T cells at baseline was associated with a better LPR response to CRM197.

Conclusions. The PCV prime-elicited memory T cell responses were associated with better and sustained humoral SPP specific IgG responses.

ClinicalTrials.gov identifier. NCT00148824.

Journal Article.  5308 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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