Journal Article

Incidence of Malignancies in HIVInfected Patients and Prognostic Role of Current CD4 Cell Count: Evidence from a Large Italian Cohort Study

M. C. F. Prosperi, A. Cozzi-Lepri, A. Castagna, C. Mussini, R. Murri, A. Giacometti, C. Torti, A. Costantini, P. Narciso, F. Ghinelli, A. Antinori and A. d'Arminio

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 50, issue 9, pages 1316-1321
Published in print May 2010 | ISSN: 1058-4838
Published online May 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/651688
Incidence of Malignancies in HIVInfected Patients and Prognostic Role of Current CD4 Cell Count: Evidence from a Large Italian Cohort Study

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The incidence of and predictors of acquired immunodeficiency syndrome-defining malignancies (ADMs) and non- ADM (NADMs) were evaluated in a large Italian cohort. The incidence of ADM and NADM was 5.0 cases per 1000 personyears of follow-up (95% confidence interval, 4.3–5.8 cases per 1000 person-years of follow-up) and 2.4 cases per 1000 person-years of follow-up (95% confidence interval, 1.9–3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM.

Journal Article.  3185 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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