Journal Article

Paradoxical Reaction to Treatment in 2 Patients with Severe Acute Paracoccidioidomycosis: A Previously Unreported Complication and Its Management with Corticosteroids

Ronaldo C. B. Gryschek, Ricardo M. Pereira, Adriana Kono, Rosely A. Patzina, Antonia T. Tresoldi, Maria A. Shikanai-Yasuda and Gil Benard

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 50, issue 10, pages e56-e58
Published in print May 2010 | ISSN: 1058-4838
Published online May 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/652290
Paradoxical Reaction to Treatment in 2 Patients with Severe Acute Paracoccidioidomycosis: A Previously Unreported Complication and Its Management with Corticosteroids

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Paradoxical reactions have never been described in patients with paracoccidioidomycosis or other deep endemic mycoses out of the context of human immunodeficiency virus infection. We describe 2 patients with an acute form of paracoccidioidomycosis who presented with a worsening of their clinical manifestations while on appropriate antifungal treatment. These manifestations were severe and required adjunct corticosteroid therapy.

Journal Article.  2122 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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