Journal Article

Use of Severity Scoring and Stratification Factors in Clinical Trials of Hospital-Acquired and Ventilator-Associated Pneumonia

Lena M. Napolitano

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue Supplement_1, pages S67-S80
Published in print August 2010 | ISSN: 1058-4838
Published online August 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/653052
Use of Severity Scoring and Stratification Factors in Clinical Trials of Hospital-Acquired and Ventilator-Associated Pneumonia

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Clinical studies of hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) enroll patients with a very wide spectrum of disease, in part, related to the patient and/or host, the causative pathogen, and the severity of the pulmonary disease, severity of illness, and other comorbidities. Studies have identified the presence of some baseline variables (eg, Acute Physiologic Assessment and Chronic Health Evaluation II score ⩽20 or absence of comorbidities) as independent predictors of survival. Incorporation of severity scoring and risk adjustment in clinical trials of HAP and VAP may be a significant advancement because it has been noted that all-cause mortality varies widely on the basis of a number of these factors. In this article, we review the use of severity scoring and risk stratification factors, including time of onset, severity of disease, scoring systems, underlying disease and comorbidities, and effects of prior antibiotic therapy (including impact on treatment effect) in clinical trials of HAP and/or VAP.

Journal Article.  6996 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.