Journal Article

Getting under the Skin: The Immunopathogenesis of <i>Streptococcus pyogenes</i> Deep Tissue Infections

Linda Johansson, Pontus Thulin, Donald E. Low and Anna Norrby-Teglund

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue 1, pages 58-65
Published in print July 2010 | ISSN: 1058-4838
Published online July 2010 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/653116
Getting under the Skin: The Immunopathogenesis of Streptococcus pyogenes Deep Tissue Infections

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Streptococcus pyogenes can cause a variety of diseases in immunocompetent individuals, from pharyngotonsillitis to life-threatening invasive diseases, such as streptococcal toxic shock syndrome, and rapidly progressing deep-tissue infections, such as necrotizing fasciitis. Necrotizing fasciitis is often seen in combination with streptococcal toxic shock syndrome, which further increases morbidity and mortality. We review here the hostpathogen interactions in the tissue milieu and discuss the use of intravenous immunoglobulin as potential adjunctive therapy in these life-threatening infections.

Journal Article.  5281 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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