Journal Article

The Two Faces of Hepatitis E Virus

James M. Hughes, Mary E. Wilson, Eyasu H. Teshale, Dale J. Hu and Scott D. Holmberg

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue 3, pages 328-334
Published in print August 2010 | ISSN: 1058-4838
Published online August 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/653943
The Two Faces of Hepatitis E Virus

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Hepatitis E virus (HEV) has at least 2 distinct epidemiological profiles: (1) large outbreaks and epidemics in developing countries, usually caused by HEV genotype 1, resulting in high morbidity and mortality among pregnant women and young children, and (2) very few symptomatic cases of HEV genotype 3, most cases without symptoms or clear source(s) of infection, but frequent seroreactivity in 5%–21% of asymptomatic persons in developed countries. We urge more epidemiological studies and public health interventions, including the promotion and development of existing and future vaccine candidates and the availability of US Food and Drug Administration-approved serological assays for this underappreciated and poorly understood virus, a major cause of disease throughout the world.

Journal Article.  5219 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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