Journal Article

<i>Mycobacterium tuberculosis</i> Microbiologic and Clinical Treatment Outcomes in a Randomized Trial of Immediate versus CD4<sup>+</sup>-Initiated Antiretroviral Therapy in HIV-Infected Adults with a High CD4<sup>+</sup> Cell Count

Gabriel Chamie, Edwin D. Charlebois, Padmini Srikantiah, Maria Walusimbi-Nanteza, Roy D. Mugerwa, Harriet Mayanja, Alphonse Okwera, Christopher C. Whalen and Diane V. Havlir

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue 3, pages 359-362
Published in print August 2010 | ISSN: 1058-4838
Published online August 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/654799
Mycobacterium tuberculosis Microbiologic and Clinical Treatment Outcomes in a Randomized Trial of Immediate versus CD4+-Initiated Antiretroviral Therapy in HIV-Infected Adults with a High CD4+ Cell Count

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In a prospective randomized, controlled trial in Uganda comparing the efficacy of antiretroviral therapy during tuberculosis therapy with the efficacy of tuberculosis therapy alone in HIV-infected patients with tuberculosis who have a CD4+ cell count >350 cells/µL, it was found that antiretroviral therapy did not accelerate microbiologic, radiographic, or clinical responses to tuberculosis therapy: 18% of participants had sputum smears positive for Mycobacterium tuberculosis after 5 months of tuberculosis therapy, despite having had negative culture results.

Trial registration. ClinicalTrials.gov identifier: NCT00078247.

Journal Article.  2311 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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