Journal Article

Absence of Neuroinvasive Disease in a Liver Transplant Recipient Who Acquired West Nile Virus (WNV) Infection from the Organ Donor and Who Received WNV Antibodies Prophylactically

Maria Cristina Morelli, Vittorio Sambri, Gian Luca Grazi, Paolo Gaibani, Anna Pierro, Matteo Cescon, Giorgio Ercolani, Francesca Cavrini, Giada Rossini, Maria Rosaria Capobianchi, Antonino Di Caro, Stefano Menzo, Pasquale Paolo Pagliaro, Florio Ghinelli, Tiziana Lazzarotto, Maria Paola Landini and Antonio Daniele Pinna

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue 4, pages e34-e37
Published in print August 2010 | ISSN: 1058-4838
Published online August 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/655146
Absence of Neuroinvasive Disease in a Liver Transplant Recipient Who Acquired West Nile Virus (WNV) Infection from the Organ Donor and Who Received WNV Antibodies Prophylactically

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We describe the first case of West Nile virus infection in Europe with transmission from donor to recipient following liver transplantation. The infection was detected in the recipient 3 days after transplantation, during the asymptomatic phase. We also report an innovative prophylactic strategy based on infusion of West Nile virus hyperimmune plasma and gamma globulins that could be effective in preventing the appearance of a neuroinvasive disease.

Journal Article.  2634 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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