Journal Article

Recurrence after Treatment for Pulmonary Multidrug-Resistant Tuberculosis

Mercedes C. Becerra, Sasha C. Appleton, Molly F. Franke, Katiuska Chalco, Jaime Bayona, Megan B. Murray and Carole D. Mitnick

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue 6, pages 709-711
Published in print September 2010 | ISSN: 1058-4838
Published online September 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/655892
Recurrence after Treatment for Pulmonary Multidrug-Resistant Tuberculosis

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We estimated the proportion of recurrence within 2 years among adults cured by individualized multidrug-resistant tuberculosis regimens in Peru. Among 310 individuals with at least 24 months of follow-up, 16 experienced an episode of recurrent tuberculosis. If we assume the worst for treatment effectiveness—that all 16 episodes were caused by the original tuberculosis strain—then 5.2% (95% confidence interval, 3.0%–8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve.

Journal Article.  1835 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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