Journal Article

Bone Disease in HIV Infection: A Practical Review and Recommendations for HIV Care Providers

Grace A. McComsey, Pablo Tebas, Elizabeth Shane, Michael T. Yin, E. Turner Overton, Jeannie S. Huang, Grace M. Aldrovandi, Sandra W. Cardoso, Jorge L. Santana and Todd T. Brown

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue 8, pages 937-946
Published in print October 2010 | ISSN: 1058-4838
Published online October 2010 | e-ISSN: 1537-6591 | DOI: https://dx.doi.org/10.1086/656412
Bone Disease in HIV Infection: A Practical Review and Recommendations for HIV Care Providers

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Low bone mineral density (BMD) is prevalent in human immunodeficiency virus (HIV)-infected subjects. Initiation of antiretroviral therapy is associated with a 2%–6% decrease in BMD over the first 2 years, a decrease that is similar in magnitude to that sustained during the first 2 years of menopause. Recent studies have also described increased fracture rates in the HIV-infected population. The causes of low BMD in individuals with HIV infection appear to be multifactorial and likely represent a complex interaction between HIV infection, traditional osteoporosis risk factors, and antiretroviral-related factors. In this review, we make the point that HIV infection should be considered as a risk factor for bone disease. We recommend screening patients with fragility fractures, all HIV-infected post-menopausal women, and all HIV-infected men ⩾50 years of age. We also discuss the importance of considering secondary causes of osteoporosis. Finally, we discuss treatment of the more severe cases of bone disease, while outlining the caveats and gaps in our knowledge.

Journal Article.  7012 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.