Journal Article

Jarisch-Herxheimer Reaction after Penicillin Therapy among Patients with Syphilis in the Era of the HIV Infection Epidemic: Incidence and Risk Factors

Chia-Jui Yang, Nan-Yao Lee, Yu-Hui Lin, Hsin-Chun Lee, Wen-Chien Ko, Chun-Hsing Liao, Cheng-Hsin Wu, Chia-Ying Hsieh, Pei-Ying Wu, Wen-Chun Liu, Ya-Chu Chang and Chien-Ching Hung

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue 8, pages 976-979
Published in print October 2010 | ISSN: 1058-4838
Published online October 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/656419
Jarisch-Herxheimer Reaction after Penicillin Therapy among Patients with Syphilis in the Era of the HIV Infection Epidemic: Incidence and Risk Factors

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The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log2 RPR increase, risk ratio [RR], 1.19; 95% confidence interval [CI], 1.04–1.37), early syphilis (RR, 8.59; 95% CI, 4.75–15.56), and prior penicillin treatment (RR, 0.39; 95% CI, 0.20–0.78).

Journal Article.  1938 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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