Journal Article

Tumefactive Demyelination— An Unusual Neurological Presentation of HIV

Alison Uriel, Rachael Stow, Leann Johnson, Anoop Varma, Daniel du Plessis, Francois Gray, Amit Herwadkar, Jeremy Holland, Penny Lewthwaite and Ed Wilkins

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 51, issue 10, pages 1217-1220
Published in print November 2010 | ISSN: 1058-4838
Published online November 2010 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/656812
Tumefactive Demyelination— An Unusual Neurological Presentation of HIV

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We describe 3 individuals infected with human immunodeficiency virus with unusual focal brain syndromes; magnetic resonance imaging revealed “open-ring” pattern space occupying lesions. After deterioration while the patientswere receiving anti-Toxoplasma therapy, brain biopsy was performed, which revealed aggressive demyelination consistent with tumefactive demyelination. Treatment with high-dose steroids resulted in complete recovery in all cases.

Journal Article.  2032 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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