Journal Article

The Absence of CD4<sup>+</sup> T Cell Count Recovery Despite Receipt of Virologically Suppressive Highly Active Antiretroviral Therapy: Clinical Risk, Immunological Gaps, and Therapeutic Options

Lidia Gazzola, Camilla Tincati, Giusi Maria Bellistré, Antonella d'Arminio Monforte and Giulia Marchetti

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 48, issue 3, pages 328-337
Published in print February 2009 | ISSN: 1058-4838
Published online February 2009 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/695852
The Absence of CD4+ T Cell Count Recovery Despite Receipt of Virologically Suppressive Highly Active Antiretroviral Therapy: Clinical Risk, Immunological Gaps, and Therapeutic Options

More Like This

Show all results sharing these subjects:

  • Infectious Diseases
  • Immunology
  • Public Health and Epidemiology
  • Microbiology

GO

Show Summary Details

Preview

Up to 30% of human immunodeficiency virus (HIV)–infected patients who are receiving long-term highly active antiretroviral therapy do not exhibit a marked increase in the CD4+ T cell count, despite achieving complete suppression of the HIV load. These patients are referred to as “immunological nonresponders.” When treating immunological nonresponders, the practicing clinician has several questions, including questions about the clinical risk associated with persistent immunodeficiency and about possible approaches to treatment that would provide clinical and immunological benefits. However, tentative answers to these questions require investigations of the mechanisms that underlie the lack of immune recovery, because only the deepest comprehension of the immunological gaps underlying functional defects will allow administration of highly targeted and efficacious treatment strategies. The aim of our review is to provide a thorough assessment of the clinical implications of a lack of increase in the CD4+ T cell count in immunological nonresponders, to examine the immunological gaps limiting recovery of the CD4+ T cell count, and to note possible therapeutic avenues, which may offer clinicians guidance regarding how to most efficaciously treat these critical patients.

Journal Article.  7012 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.