Journal Article

Vertebral Blastomycosis with Paravertebral Abscess: Report of Eight Cases and Review of the Literature

Michael Saccente, Robert S. Abernathy, Peter G. Pappas, Hemendra R. Shah and Robert W. Bradsher

in Clinical Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 26, issue 2, pages 413-418
Published in print February 1998 | ISSN: 1058-4838
Published online February 1998 | e-ISSN: 1537-6591 | DOI: http://dx.doi.org/10.1086/clinids/26.2.413
Vertebral Blastomycosis with Paravertebral Abscess: Report of Eight Cases and Review of the Literature

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Bone is the third most frequent site of disease in patients with blastomycosis, and the vertebrae are among the bones affected most often. We describe the clinical features and treatment of eight patients with vertebral blastomycosis and review the literature regarding this disease. All eight patients had destructive vertebral lesions evident on radiographs, and all had clinical or radiographic evidence of a contiguous abscess. The lower thoracic or lumbar regions were affected most often. Fever and skin lesions typical of blastomycosis were variably present. All but one patient had an abnormal chest radiograph. Treatment included long-term antifungal therapy and drainage of large fluid collections. Five of the eight patients were cured of their disease. Of the other 3 patients, 1 is still receiving therapy and is probably cured, 1 died of blastomycosis, and the status of 1 is unknown. In areas of endemicity, blastomycosis should be a diagnostic consideration for any patient with a destructive vertebral lesion.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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