Chapter

Phase I Research and the Meaning of ‘Prospect of Direct Benefit’

Lainie Friedman Ross

in Children in Medical Research

Published in print February 2006 | ISBN: 9780199273287
Published online May 2006 | e-ISBN: 9780191603655 | DOI: http://dx.doi.org/10.1093/0199273286.003.0007

Series: Issues in Biomedical Ethics

Phase I Research and the Meaning of ‘Prospect of Direct Benefit’

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This chapter examines the issue of whether phase I pediatric oncology trials offer the prospect of direct benefit. Phase I research is carried out to determine toxicity; the possibility of direct benefit is secondary to the objectives of the study. Focusing exclusively on whether phase I trials could be interpreted as offering the prospect of direct benefit fails to acknowledge the moral relevance of the researchers’ intent. If intentions matter, then phase I studies cannot be said to offer the prospect of direct benefit.

Keywords: direct benefit; pediatric oncology; medical research; pediatric research

Chapter.  5656 words. 

Subjects: Moral Philosophy

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