Journal Article

Ghrelin fluctuation, what determines its production?

Xuefeng Yin, Yin Li, Geyang Xu, Wenjiao An and Weizhen Zhang

in Acta Biochimica et Biophysica Sinica

Published on behalf of Institute of Biochemistry and Cell Biology, SIBS, CAS

Volume 41, issue 3, pages 188-197
Published in print March 2009 | ISSN: 1672-9145
Published online March 2009 | e-ISSN: 1745-7270 | DOI: https://dx.doi.org/10.1093/abbs/gmp001
Ghrelin fluctuation, what determines its production?

Show Summary Details

Preview

Ghrelin, a 28 amino acid gut brain peptide, acts as an endogenous ligand for its receptor, the growth hormone secretagogue receptor, to exercise a variety of functions ranging from stimulation of growth hormone secretion, regulation of appetite and energy metabolism, and cell protection to modulation of inflammation. This review summarizes the advance in the regulation of ghrelin expression and secretion. We introduce the structure of ghrelin promoter, the processing and modification of ghrelin precursor, and the regulation mechanism in these processes. Then we discuss factors found to be important in the regulation of ghrelin production, including nutrients, hormones, and autonomic nervous system. Finally, we outline the alteration in the level of ghrelin in certain physiological and pathological status.

Keywords: ghrelin; regulation; diet; secretion; biosynthesis

Journal Article.  5531 words.  Illustrated.

Subjects: Biochemistry

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.