Chapter

5-HT in migraine: evidence from 5-HT receptor antagonists for a neuronal aetiology

J.R. Fozard

in Migraine: A Spectrum of Ideas

Published in print March 1990 | ISBN: 9780192618108
Published online March 2012 | e-ISBN: 9780191724305 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192618108.003.0011
5-HT in migraine: evidence from 5-HT receptor antagonists for a neuronal aetiology

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The fact that antagonists at certain 5-HT receptor subtypes are effective in the prophylaxis or treatment of migraine implicates the endogenous amine in a causal role in the condition. On the basis of the properties and selectivities of such antagonists, this chapter discusses the potential significance of 5-HTlc, 5-HT2, and 5-HT3 receptors in the initiation, development, and symptomatology of migraine. The likely source(s) of the 5-HT needed to stimulate these sites are considered, and a hypothesis is proposed to implicate the activity of the 5-HT neurones arising in the mid-brain raphe nuclei in a key role in the aetiology of migraine. The ideas discussed here are developments and extensions of those expressed over a number of years in several review articles and are by no means unique.

Keywords: 5-HT receptor subtypes; neuronal aetiology; treatment of migraine; endogenous amine; symptomatology; 5-HT neurones

Chapter.  8408 words.  Illustrated.

Subjects: Neuroscience

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