5-HT in migraine: evidence from 5-HT<sub>1</sub>-like receptor agonists for a vascular aetiology

P.P.A. Humphrey, W. Feniuk and M.J. Perren

in Migraine: A Spectrum of Ideas

Published in print March 1990 | ISBN: 9780192618108
Published online March 2012 | e-ISBN: 9780191724305 | DOI:
5-HT in migraine: evidence from 5-HT1-like receptor agonists for a vascular aetiology

Show Summary Details


Regardless of the many considerations, GR43175 has been shown to be effective when administered subcutaneously and orally as well as when administered intravenously in the treatment of acute migraine. It is now in phase III clinical trials and promises to provide a major breakthrough in migraine therapy. Importantly, further studies on its clinical mechanism of action are in progress and they will, it is hoped, be invaluable in elucidating the pathogenesis of migraine and vascular headache.

Keywords: vascular aetiology; acute migraine; treatment of migraine; clinical trials; vascular headache; pathogenesis

Chapter.  10736 words.  Illustrated.

Subjects: Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.