The anxiogenic effect may be relevant to migraine, as anxiety or stress are candidates for precipitating attacks of migraine, and it is therefore of great interest that Brewerton et al. recently reported that m-CPP precipitated headache in both control and migrainous subjects with a significantly greater incidence in the latter group. Seven out of eight of them reported that the headaches could not be distinguished from their naturally occurring symptoms, except possibly for the absence of prodromal signs. This work and findings of the current study may suggest new avenues for migraine research. At the least, they raise a number of questions. This chapter summarizes the evidence that the anxiogenic effect of m-CPP is mediated by 5-HTlc receptors, that it is not merely a consequence of the hypolocomotor effect of m-CPP, and that it may also have implications for the mechanism and treatment of migraine.
Keywords: m-chlorophenylpiperazine; migraine attack; anxiogenic effect; 5-HTlc receptors; treatment of migraine; migraine precipitant
Chapter. 3224 words.
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