Chapter

5-HT receptors and migraine

Pramod R. Saxena

in Migraine: A Spectrum of Ideas

Published in print March 1990 | ISBN: 9780192618108
Published online March 2012 | e-ISBN: 9780191724305 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192618108.003.0014
5-HT receptors and migraine

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Migraine is a vascular headache but its pathophysiology is complex and multifactorial. Of the many pathophysiological factors that are implicated in migraine, changes in the metabolism of 5-hydroxytryptamine (5-HT) are the best documented. During the headache phase of migraine, urinary excretion of 5-hydroxyindoleacetic acid increases, whereas the blood 5-HT concentration decreases. Furthermore, in migraine patients reserpine precipitates a headache that can be alleviated by 5-HT. In the light of recent developments in the characterization and classification of the receptors for 5-HT, this article aims to discuss the relationship between the neural and cephalovascular 5-HT receptors and the antimigraine action of drugs.

Keywords: vascular headache; 5-hydroxytryptamine; pathophysiology; urinary excretion; 5-HT receptors; action of drugs

Chapter.  2624 words. 

Subjects: Neuroscience

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