Chapter

Peptidergic mechanisms in human intracranial and extracranial arteries

Lars Edvinsson, Inger Jansen and Rolf Uddman

in Migraine: A Spectrum of Ideas

Published in print March 1990 | ISBN: 9780192618108
Published online March 2012 | e-ISBN: 9780191724305 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192618108.003.0017
Peptidergic mechanisms in human intracranial and extracranial arteries

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Migraine attacks are conventionally thought to involve a dysfunction in the regulation of tone in intra- and extracranial blood vessels. A number of agents have been suggested as responsible for the altered vasomotor responses seen in conjunction with migraine attacks. Previous histochemical studies have shown that human cerebral arteries are surrounded by adrenergic and cholinergic nerve fibres. In addition, peptide-containing nerve fibres, such as neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP), have been observed around the cerebral blood vessels of laboratory animals. Few studies have been carried out on human temporal and cerebral arteries, but none on meningeal arteries. This chapter examines the distribution of NPY-, VIP-, SP- and CGRP-immunoreactive fibres around the three types of human cranial arteries and compared the pharmacological effects of the perivascularly located neuropeptides on arterial segments.

Keywords: extracranial blood vessels; migraine attack; vasoactive intestinal peptide; neuropeptide Y; calcitonin gene-related peptide; neuropeptides

Chapter.  4121 words.  Illustrated.

Subjects: Neuroscience

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