Chapter

Differential abnormalities in signal transduction in migraine and cluster headache

J. de Belleroche

in Migraine: A Spectrum of Ideas

Published in print March 1990 | ISBN: 9780192618108
Published online March 2012 | e-ISBN: 9780191724305 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192618108.003.0023
Differential abnormalities in signal transduction in migraine and cluster headache

Show Summary Details

Preview

Over the past few years a biochemical approach has been used to study the pathogenesis of migraine by looking at transduction mechanisms which would be common to many agents that are putative trigger factors in migraine and would also be common targets for a wide range of drug treatments. Hormones, dietary factors, neurogenic agents such as neurotransmitters, neuropeptides, and other neuromodulators and vasoactive agents are all implicated, most of which would mediate their actions through receptors in the cell membrane. Receptor activation is associated with the generation of second messengers — cyclic AMP (cAMP) from adenylate cyclase, and inositol trisphosphate and diacylglycerol from the polyphosphoinositide system. The second messengers in turn produce their effects by activation of protein kinases or by mobilization of calcium. A number of prophylactic treatments would affect these pathways.

Keywords: transduction mechanisms; drug treatments; dietary factors; neurogenic agents; cyclic AMP; polyphosphoinositide system

Chapter.  3121 words.  Illustrated.

Subjects: Neuroscience

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.