Merton Sandler

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI:

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It is hard to believe that only ten years have gone by since Peroutka and Snyder's breakthrough in the 5-hydroxytryptamine (5-HT, serotonin) receptor field. There were good precedents with adrenoceptors and histamine receptors and it seemed sensible that multiple 5-HT receptors would also exist, but to find them one had to wait until the technology was right. But with a combination of receptor binding technology and classical pharmacology over the past decade everything fell into place. One of the most striking papers to emerge during the past year was that of Julius et al. who transfected 5-HTlc receptors into rat fibroblasts where they are not normally present. They found they were dealing with a protooncogene, and when these altered fibroblasts were transplanted into the nude mouse they gave rise to tumour formation. Nagatsu and his colleagues in Japan have been able to transfer the tyrosine hydroxylase cDNA into non-neuronal cells, for future use in intracerebral grafting. This is but one example of many that will be found within this volume of how the curtain is beginning to lift on many areas of biological psychiatry and, most particularly, on the subtle role of 5-HT.

Keywords: 5-hydroxytryptamine; adrenoceptors; histamine receptors; protooncogene; intracerebral grafting; biological psychiatry

Chapter.  576 words. 

Subjects: Neuroscience

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