An overview of 5-hydroxytryptamine receptor families

Stephen J. Peroutka and Anne W. Schmidt

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI:
An overview of 5-hydroxytryptamine receptor families

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In the past decade, many 5-hydroxytryptamine (5-HT, serotonin) receptor subtypes have been characterized. Many of these subtypes were identified. More recently, molecular biological studies have identified numerous distinct amino acid sequences that appear to represent even more pharmacologically distinct receptor subtypes. This chapter summarizes the current status of 5-HT receptors using a framework in which those with similar characteristics are considered as a ‘family’ of receptors. The identification and characterization of receptor subtypes have significant clinical implications. Theoretically, each subtype provides a specific target site that can be pharmacologically manipulated. The goal of the basic scientific research is to identify the potential functional significance of each 5-HT receptor subtype.

Keywords: serotonin; amino acid sequences; 5-HT receptors; receptor subtypes; clinical implication; identification and characterization

Chapter.  9287 words. 

Subjects: Neuroscience

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