cAMP-dependent binding proteins and endogenous phosphorylation after antidepressant treatment

G. Racagni, D. Tinelli, E. Bianchi, N. Brunello and J. Perez

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI:
cAMP-dependent binding proteins and endogenous phosphorylation after antidepressant treatment

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Among the most significant changes induced in monoaminergic neurones by chronic antidepressant treatment are: reduction in tyrosine hydroxylase activity, decrease in the ability of NA to stimulate the activity of adenylate cyclase, and reduction in the concentration of noradrenergic and serotonergic receptors. Many synaptic and trans-synaptic mechanisms may participate in the desensitization of neurotransmitter receptors after chronic treatment with antidepressants. The most commonly described effector mechanism beyond the second messengers depends on protein phosphorylation mediated by activation of specific protein serine-threonine kinases. Components of the protein phosphorylation system are associated with the cytoskeleton. This chapter investigates whether the cAMP-dependent phosphorylation system associated with microtubules, which are constituents of neuronal cytoskeleton, could be an intracellular target for antidepressants acting on NA and 5-HT neurones.

Keywords: noradrenaline; neurotransmitters; therapeutic effects; monoaminergic neurons; tyrosine hydroxylase; phosphorylation

Chapter.  2469 words.  Illustrated.

Subjects: Neuroscience

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