Chapter

Experimental tests of the 5-HT receptor imbalance theory of affective disturbance

J. F. W. Deakin, F. S. Guimaraes, M. Wang and R. Hensman

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192620118.003.0012
Experimental tests of the 5-HT receptor imbalance theory of affective disturbance

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Symptoms of anxiety and depression usually coexist. Scores on anxiety rating scales strongly predict scores on depression rating scales. Symptoms of anxiety predict symptoms of depression. Symptoms of anxiety may ante-date and outlast depressive symptoms, and depression may be a higher level of affective disturbance than anxiety. However, there is no antithesis between the two sets of symptoms. The same treatments are effective in both and the most effective is treatment with 5-hydroxytryptamine (5-HT, serotonin) re-uptake-blocking antidepressants. It is therefore a very considerable paradox that excessive 5-HT neurotransmission has been associated with symptoms of anxiety whereas deficient 5-HT function has been associated with depressive illness.

Keywords: anxiety rating; depression; depressive symptoms; re-uptake-blocking antidepressants; 5-HT neurotransmissions

Chapter.  4596 words.  Illustrated.

Subjects: Neuroscience

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