Anxiogenic effect of the 5-HT<sub>1C</sub> agonist m-chlorophenylpiperazine

G. Curzon, G. A. Kennett and P. Whitton

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI:
Anxiogenic effect of the 5-HT1C agonist m-chlorophenylpiperazine

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The earlier literature on l-(3-chlorophenyl)piperazine (m-CPP) and l-[3-(trifluoromethyl)phenyl] piperazine (TFMPP) describes these compounds mainly as agonists at the IB subtype of 5-hydroxytryptamine (5-HT, serotonin) receptors. However, many findings suggest that their hypolocomotor and hypophagic effects are mediated by stimulation of 5-HTlc receptors. As m-CPP causes anxiety in humans it was investigated whether m-CPP and TFMPP had anxiogenic-like effects in rats. The results indicate that this occurs and is mediated by hippocampal 5-HTlc receptors.

Keywords: hypolocomotor; TFMPP; m-chlorophenylpiprazine; trifluoromethylphenyl piprazine; anxiogenic; 5-hydroxytryptamine

Chapter.  3995 words. 

Subjects: Neuroscience

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