The earlier literature on l-(3-chlorophenyl)piperazine (m-CPP) and l-[3-(trifluoromethyl)phenyl] piperazine (TFMPP) describes these compounds mainly as agonists at the IB subtype of 5-hydroxytryptamine (5-HT, serotonin) receptors. However, many findings suggest that their hypolocomotor and hypophagic effects are mediated by stimulation of 5-HTlc receptors. As m-CPP causes anxiety in humans it was investigated whether m-CPP and TFMPP had anxiogenic-like effects in rats. The results indicate that this occurs and is mediated by hippocampal 5-HTlc receptors.
Keywords: hypolocomotor; TFMPP; m-chlorophenylpiprazine; trifluoromethylphenyl piprazine; anxiogenic; 5-hydroxytryptamine
Chapter. 3995 words.
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