Chapter

Serotonin in obsessive-compulsive disorder: a causal connection or more monomania about a major monoamine?

Thomas R. Insel

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192620118.003.0018
Serotonin in obsessive-compulsive disorder: a causal connection or more monomania about a major monoamine?

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Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a number of psychiatric syndromes, but it is obsessive-compulsive disorder (OCD) that currently provides the most compelling evidence of a connection between serotonin and psychopathology. The precise nature of this connection remains unclear — in spite of strong evidence implicating serotonin in the treatment of OCD, there is a lack of a clear model of serotonergic dysfunction to explain the pathophysiology of this syndrome. This chapter reviews the current literature about serotonin and OCD to examine two questions: do OCD patients have an abnormality in serotonergic neurotransmission and, if so, what is the nature of this abnormality?

Keywords: obsessive-compulsive disorder; serotonin; sychopathology; serotonergic dysfunction; pathophysiology; serotonergic neurotransmission

Chapter.  13155 words.  Illustrated.

Subjects: Neuroscience

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