Chapter

Monoamines, glucose metabolism, and impulse control

Markku Linnoila and Matti Virkkunen

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192620118.003.0019
Monoamines, glucose metabolism, and impulse control

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Many animal and human studies have explored biochemical concomitants of aggressive and self-destructive behaviours. A small number of these studies have used pharmacological manipulations to provoke or reduce such behaviours. A common factor in these investigations is central nervous system (CNS) serotonin (5hydroxytryptamine, 5-HT); decreasing serotonergic functioning is conducive of aggressive and impulsive behaviours, increasing it reduces such behaviours. Another factor associated with impulsive, violent offences in some humans is a tendency to become mildly hypoglycaemic after an oral glucose load. Such mild hypoglycaemia is a state associated with irritability and impulsivity. This review develops the arguments that CNS serotonin metabolism may, to some extent, control glucose metabolism and that reduced central serotonin turnover may be causally linked to hypoglycaemic tendency in impulsive violent offenders and fire-setters.

Keywords: monoamines; glucose metabolism; biochemical concomitants; impulse control; pharmacological manipulations; self-destructive behaviours

Chapter.  9658 words. 

Subjects: Neuroscience

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