Chapter

5-Hydroxytryptamine in the control of feeding and its possible implications for appetite disturbance

G. Curzon

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192620118.003.0020
5-Hydroxytryptamine in the control of feeding and its possible implications for appetite disturbance

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This chapter focuses on the relationships between 5-hydroxytryptamine (5-HT, serotonin) and feeding and describes both neurochemical and pharmacological findings. Neurochemical research has centred on the effects of feeding on brain 5-HT metabolism in laboratory animals, but its effects on the availability of 5-HT to receptors were only reported recently. Pharmacological research has shown that serotonergic drugs influence appetite. Thus the 5-HT system is relevant to appetite disorders and their treatment. Taken together, these results imply (but do not prove) that effects of feeding or starvation on 5-HT function may be involved in the control of appetite. Testing such hypotheses demands work on central 5-HT function in humans with appetite disorders.

Keywords: 5-Hydroxytryptamine; appetite disturbance; neurochemical inputs; serotonergic drugs; neurochemical research

Chapter.  11095 words. 

Subjects: Neuroscience

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