Chapter

Summary

Arvid Carlsson

in 5-Hydroxytryptamine in Psychiatry

Published in print February 1991 | ISBN: 9780192620118
Published online March 2012 | e-ISBN: 9780191724725 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192620118.003.0025
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This volume began with overviews of pre- and post-synaptic aspects of the serotonergic system which emphasized its complexity and heterogeneity. This complexity is to be expected, given that the serotonergic system is phylogenetically probably the oldest of the monoaminergic systems. Receptor families must be emphasized rather than subtypes. There is also considerable heterogeneity at the pre-synaptic level; the nerve fibres that terminate in the hypothalamus, for example, have much coarser varicosities than those terminating in the cerebral cortex. This has consequences for sensitivity and for vulnerability to neurotoxins.

Keywords: serotonergic system; heterogeneity; hypothalamus; neurotoxins; cerebral system; monoaminergic systems

Chapter.  1589 words. 

Subjects: Neuroscience

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