Chapter

Pharmacological principles for analysing responses of vascular smooth muscle

Graeme R. Martin and Heather Giles

in The Pharmacology of Vascular Smooth Muscle

Published in print February 1996 | ISBN: 9780192623874
Published online March 2012 | e-ISBN: 9780191724671 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192623874.003.0001
Pharmacological principles for analysing responses of vascular smooth muscle

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Numerous methods exist which enable the vascular effects of drugs to be studied in vivo as well as in vitro. However, the quantitative study of drug–receptor interactions in blood vessels requires precise control over the experimental conditions and this is best achieved using isolated, intact vascular tissues physiologically maintained in an organ-bath. Fortunately, carefully prepared blood vessel segments retain much of their functional integrity making it possible to assess, in a meaningful way, the effects of vasoactive drugs in the target tissue. This chapter outlines the pharmacological principles underlying the quantitative study of agonist and antagonist drug effects on vascular smooth muscle and looks at specific practical conditions which must be observed to ensure that the information obtained is robust and reliable.

Keywords: vascular smooth muscle; blood vessels; antagonist drugs; vasoactive drugs

Chapter.  8435 words.  Illustrated.

Subjects: Neuroscience

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