Chapter

In vivo techniques and analysis

J. A. Angus, C. E. Wright, K. Sudhir and G. J. Jennings

in The Pharmacology of Vascular Smooth Muscle

Published in print February 1996 | ISBN: 9780192623874
Published online March 2012 | e-ISBN: 9780191724671 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192623874.003.0004
In vivo techniques and analysis

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When scientists aim to understand the mechanism of action of a drug on the vascular system, they will seek the ultimate experiment in a chosen test system stripped of its layers of complex interactions to maximize analytical power and minimize external influences. With such a controlled assay design, scientists may achieve some measure of analytical certainty that their vascular drug is behaving in a direct predictable manner. Such a bioassay system may be a smooth muscle cell membrane preparation, cell culture system, or isolated large or small artery mounted in a myograph or organ chamber. But in the end, these scientists will, theoretically at least, have to extrapolate their findings to the more integrated system of a vascular bed and ultimately the human circulation.

Keywords: vascular system; bioassays; analytical power; assay design; organ chambers; myograph

Chapter.  9750 words.  Illustrated.

Subjects: Neuroscience

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