Chapter

Cotransmission

G. Burnstock and V. Ralevic

in The Pharmacology of Vascular Smooth Muscle

Published in print February 1996 | ISBN: 9780192623874
Published online March 2012 | e-ISBN: 9780191724671 | DOI: http://dx.doi.org/10.1093/acprof:oso/9780192623874.003.0009
Cotransmission

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For many years researchers' understanding of neurotransmission has been dominated by the concept that one neurone releases only a single transmitter, known as Dale's principle. This idea arose from a widely adopted misinterpretation of Dale's suggestion in 1935 that the same neurotransmitter was stored in and released from all terminals of a single neurone, a suggestion which did not specifically preclude the possibility that more than one transmitter may be associated with the same neurone. Several lines of evidence emerged which were inconsistent with the single transmitter concept and it is now known that individual neurones contain and can release a large number and variety of substances which are capable of influencing target cells — this phenomenon of cotransmission is widespread involving virtually all known transmitter systems.

Keywords: neurotransmission; neurones; Dale; cotransmission; target cells; transmitter systems

Chapter.  9391 words.  Illustrated.

Subjects: Neuroscience

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